Contemporary Surgical Management of Colorectal Cancer in Lynch Syndrome: Considering the Implications of Known Genotype.

Abstract excerpt

BACKGROUND: Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in mismatch repair (MMR) genes, accounting for 1%-3% of all colorectal cancer (CRC) diagnoses. It is associated with an elevated lifetime CRC risk of 30%-80% and predisposes individuals to various extra-colonic malignancies. Advances in genetic profiling have refined our understanding of LS, offering opportunities to...

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