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Article

Using biological knowledge to uncover the mystery in the search for epistasis in genome-wide association studies.

Annals of human genetics - 1 Jan 2011

Ritchie Marylyn D

Abstract excerpt

The search for the missing heritability in genome-wide association studies (GWAS) has become an important focus for the human genetics community. One suspected location of these genetic effects is in gene-gene interactions, or epistasis. The computational burden of exploring gene-gene interactions in the wealth of data generated in GWAS, along with small to moderate sample sizes, have led to epistasis being an...

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Identifiers

PMID: 21158748
DOI: 10.1111/j.1469-1809.2010.00630.x
PMCID: PMC3092784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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