Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using biological knowledge to uncover the mystery in the search for epistasis in genome-wide association studies.

Annals of human genetics - 1 Jan 2011

Ritchie Marylyn D

Abstract excerpt

The search for the missing heritability in genome-wide association studies (GWAS) has become an important focus for the human genetics community. One suspected location of these genetic effects is in gene-gene interactions, or epistasis. The computational burden of exploring gene-gene interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epistasis, Genetic
Share to Genome-Wide Association Study
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 21158748
DOI: 10.1111/j.1469-1809.2010.00630.x
PMCID: PMC3092784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21158748-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using biological knowledge to uncover the mystery in the search for epistasis in genome-wide association studies.PMID 21158748Read ↗

Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies.Semantic proximity Read ↗

Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studiesSemantic proximity Read ↗

A fast algorithm for learning epistatic genomic relationships.Semantic proximity Read ↗

Analysis of Gene-Gene Interactions.Semantic proximity Read ↗

Two-Stage Testing for Epistasis: Screening and Verification.Semantic proximity Read ↗

Using biological networks to search for interacting loci in genome-wide association studies.Semantic proximity Read ↗

Pathway Analysis within Multiple Human Ancestries Reveals Novel Signals for Epistasis in Complex TraitsSemantic proximity Read ↗

Potential synthetic associations created by epistasisSemantic proximity Read ↗

GWIS--model-free, fast and exhaustive search for epistatic interactions in case-control GWAS.Semantic proximity Read ↗

Novel Methods for Epistasis Detection in Genome-Wide Association StudiesSemantic proximity Read ↗

Novel methods for epistasis detection in genome-wide association studies.Semantic proximity Read ↗

Biological knowledge-driven analysis of epistasis in human GWAS with application to lipid traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.