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The RNA Revolution in the Central Molecular Biology Dogma Evolution.

International journal of molecular sciences - 26 Nov 2024

Haseltine William A, Patarca Roberto

Abstract excerpt

Human genome projects in the 1990s identified about 20,000 protein-coding sequences. We are now in the RNA revolution, propelled by the realization that genes determine phenotype beyond the foundational central molecular biology dogma, stating that inherited linear pieces of DNA are transcribed to RNAs and translated into proteins. Crucially, over 95% of the genome, initially considered junk DNA between...

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PMID: 39684407
DOI: 10.3390/ijms252312695
PMCID: PMC11641533

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