Article
Prioritization of candidate SNPs in colon cancer using bioinformatics tools: an alternative approach for a cancer biologist.
Interdisciplinary sciences, computational life sciences - 1 Dec 2010
George Priya Doss C, Rajasekaran R, Arjun P, Sethumadhavan Rao
Abstract excerpt
The genetics of human phenotype variation and especially, the genetic basis of human complex diseases could be understood by knowing the functions of Single Nucleotide Polymorphisms (SNPs). The main goal of this work is to predict the deleterious non-synonymous SNPs (nsSNPs), so that the number of SNPs screened for association with disease can be reduced to that most likely alters gene function. In this work by...
Topics
- Algorithms
- Colonic Neoplasms
- Computational Biology
- Gene Expression
- Genes, Neoplasm
- Genome
- Haplotypes
- Humans
- Mutation
- Phenotype
- Polymorphism, Single Nucleotide