Article
Speeding disease gene discovery by sequence based candidate prioritization.
BMC bioinformatics - 14 Mar 2005
Adie Euan A, Adams Richard R, Evans Kathryn L, Porteous David J, Pickard Ben S
Abstract excerpt
BACKGROUND: Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is reduced by matching functional annotation to knowledge of the disease or phenotype in question. However, here we show that disease genes share patterns of sequence-based features that can provide a good basis for automatic...
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