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Article

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.

Diabetologia - 1 Mar 2011

Vangipurapu J, Stančáková A, Pihlajamäki J, Kuulasmaa T M, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M

Abstract excerpt

AIMS/HYPOTHESIS: Of the confirmed type 2 diabetes susceptibility loci only a few are known to affect insulin sensitivity. We examined the association of indices of hepatic and adipocyte insulin resistance (IR) with 19 confirmed type 2 diabetes risk loci in a large population-based study. METHODS: Non-diabetic participants (n = 8,460, age 57.3 ± 7.0 years, BMI 26.8 ± 3.8 kg/m(2); mean ± SD) from a population-based...

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Identifiers

PMID: 21153532
DOI: 10.1007/s00125-010-1977-4

Genes

HHEX
KCNJ11
NOTCH2
ADAMTS9
CDKAL1
JAZF1
KCNQ1
PPARG
TSPAN8
WFS1

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