Article
Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase.
PloS one - 30 Nov 2010
van Schaijk Ben C L, Vos Martijn W, Janse Chris J, Sauerwein Robert W, Khan Shahid M
Abstract excerpt
Genetically-modified mutants are now indispensable Plasmodium gene-function reagents, which are also being pursued as genetically attenuated parasite vaccines. Currently, the generation of transgenic malaria-parasites requires the use of drug-resistance markers. Here we present the development of...
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