Article
Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function.
Developmental biology - 1 Feb 2014
Xu Xiaoou, Shuen Wai Ho, Chen Chen, Goudevenou Katerina, Jones Peter, Sablitzky Fred
Abstract excerpt
Swap70 functions as a guanine nucleotide exchange factor for Rac and RhoA regulating F-actin cytoskeletal rearrangements and playing a crucial role in mammalian cell activation, migration, adhesion and invasion. Here we show that the zebrafish orthologue, Swap70b, is required for convergent and e...
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