Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins.

Diabetologia - 1 Aug 2005

Lehtovirta M, Kaprio J, Groop L, Trombetta M, Bonadonna R C

Abstract excerpt

AIMS/HYPOTHESIS: The genetic architecture of model-derived parameters of beta cell function has never been assessed. Therefore, we estimated heritability (h(2)) for model-derived phenotypes of insulin secretion in twins. METHODS: Thirty-three monozygotic (MZ) and 23 dizygotic (DZ) twin pairs from the Finnish Twin Cohort Study underwent an OGTT (plasma glucose/C-peptide at 0, 30, 60, 90 and 120 min). A subset of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Factual
Share to Finland
Share to Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Clamp Technique

Share to Glucose Tolerance Test

Share to Islets of Langerhans

Share to Twins, Dizygotic

Share to Twins, Monozygotic

Source

Identifiers

PMID: 15977011
DOI: 10.1007/s00125-005-1815-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins.PMID 15977011Read ↗

Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins.Semantic proximity Read ↗

Heritability of Insulin Secretion, Peripheral and Hepatic Insulin Action, and Intracellular Glucose Partitioning in Young and Old Danish TwinsSemantic proximity Read ↗

Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) ModelSemantic proximity Read ↗

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function.Semantic proximity Read ↗

High heritability and genetic correlation of intravenous glucose- and tolbutamide-induced insulin secretion among non-diabetic family members of type 2 diabetic patients.Semantic proximity Read ↗

Comprehensive validation of fasting- and oral glucose tolerance test-based indices of insulin secretion against gold-standard measuresSemantic proximity Read ↗

Genetic and phenotypic correlations between surrogate measures of insulin release obtained from OGTT data.Semantic proximity Read ↗

Human Physiology of Genetic Defects Causing Beta-cell Dysfunction.Semantic proximity Read ↗

Heritability of Curve Patterns in Oral Glucose Tolerance Test.Semantic proximity Read ↗

Type 2 diabetes mellitus: a disease of the governance of the glucose-insulin system: an experimental metabolic control analysis study.Semantic proximity Read ↗

Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study.Semantic proximity Read ↗

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to Type 2 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.