Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone.

Journal of hypertension - 1 Mar 2011

Sonoyama Kazuhiko, Greenstein Adam S, Micheletti Rosella, Ferrari Patrizia, Schiavone Antonio, Aghamohammadzadeh Reza, Withers Sarah B, Tripodi Grazia, Ferrandi Mara, Heagerty Anthony M

Abstract excerpt

BACKGROUND: Damage to renal artery myogenic tone is universally associated with progressive kidney damage. Recently, we have observed that mutations in the beta adducin subunit are associated with proteinuria in the Milan rat. Because of the role of adducin as a component of the cytoskeleton we hypothesized that this mutation may be associated with changes in myogenic tone. METHODS AND RESULTS: Congenic rats were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Proteinuria
Share to Vasoconstriction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Age Factors

Share to Blood Pressure

Share to Calmodulin-Binding Proteins

Share to Endothelial Cells

Share to Organ Specificity

Share to Phenylephrine

Source

Identifiers

PMID: 21150638
DOI: 10.1097/HJH.0b013e328341e1a1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone.PMID 21150638Read ↗

α- and β-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathySemantic proximity Read ↗

The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.Semantic proximity Read ↗

Adducin and hypertension.Semantic proximity Read ↗

Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm.Semantic proximity Read ↗

Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.Semantic proximity Read ↗

Renal mechanisms of genetic hypertension: from the molecular level to the intact organism.Semantic proximity Read ↗

A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease.Semantic proximity Read ↗

Glomerular barrier dysfunction in glomerulosclerosis- resistant Milan rats with experimental diabetes: the role of renal haemodynamics.Semantic proximity Read ↗

Hypertensive glomerular damage as revealed by the expression of alpha-smooth muscle actin and non-muscle myosin.Semantic proximity Read ↗

Characterisation and chromosomal localisation of the rat alpha- and beta-adducin-encoding genes.Semantic proximity Read ↗

Alpha-adducin gene polymorphism and cardiovascular phenotypes in a general population.Semantic proximity Read ↗

Polymorphism of gamma-adducin gene in genetic hypertension and mapping of the gene to rat chromosome 1q55.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.