Article
Glomerular barrier dysfunction in glomerulosclerosis- resistant Milan rats with experimental diabetes: the role of renal haemodynamics.
The Journal of pathology - 1 Oct 2007
Pugliese G, Ricci C, Iacobini C, Menini S, Fioretto P, Ferrandi M, Giardino L A, Armelloni S, Mattinzoli D, Rastaldi M P, Pugliese F
Abstract excerpt
Rats of the Milan hypertensive strain (MHS) are resistant to both hypertensive and diabetic renal disease. Genetically determined hypertrophy of intrarenal arteries has been suggested as the putative mechanism preventing transmission of systemic hypertension to the glomerular microcirculation or diabetes-induced loss of autoregulation, which lead to glomerular hypertension and consequent podocyte injury and...
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