Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.

Molecular biology of the cell - 1 Oct 2008

González-Aguilera Cristina, Tous Cristina, Gómez-González Belén, Huertas Pablo, Luna Rosa, Aguilera Andrés

Abstract excerpt

The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in yeast. mRNA export factors such as Thp1-Sac3 also affect genome integrity, but their mutations have other phenotypes different from those of THO/TREX. Sus1 is a novel component of SAGA transcription factor that also associates with Thp1-Sac3, but little is known about its effect on genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Genomic Instability

Share to Nucleocytoplasmic Transport Proteins

Share to Porins

Share to Ribonucleoproteins

Share to RNA, Catalytic

Source

Open in PubMed Open full text

Identifiers

PMID: 18667528
DOI: 10.1091/mbc.e08-04-0355
PMCID: PMC2555943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.PMID 18667528Read ↗

Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.Semantic proximity Read ↗

Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.Semantic proximity Read ↗

Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants.Semantic proximity Read ↗

Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism.Semantic proximity Read ↗

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.Semantic proximity Read ↗

An unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching.Semantic proximity Read ↗

New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.Semantic proximity Read ↗

Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1.Semantic proximity Read ↗

An intronic RNA structure modulates expression of the mRNA biogenesis factor Sus1.Semantic proximity Read ↗

Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Semantic proximity Read ↗

Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity.Semantic proximity Read ↗

The Prp19C subunits Cwc15 and Syf2 function in TREX occupancy and transcription elongationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.