Article
Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment
12 Dec 2009
Abstract excerpt
Of all the major organ systems in the body, the ovaries of females are the first to exhibit impaired function with advancing age. Until recently, traditional thinking was that female mammals are provided with a non-renewable pool of oocyte-containing follicles at birth that are depleted during postnatal life to exhaustion, driving ovarian failure. However, a growing body of evidence, including the isolation of...
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