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Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice

1 Dec 2014

Abstract excerpt

Whether or not oocyte regeneration occurs in adult life has been the subject of much debate. In this study, we have traced germ-cell lineages over the life spans of three genetically modified mouse models and provide direct evidence that oogenesis does not originate from any germline stem cells (GSCs) in adult mice. By selective ablation of all existing oocytes in a Gdf9-Cre;iDTR mouse model, we have demonstrated...

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PMID: 25453063
DOI: 10.1073/pnas.1421047111

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