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Article

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

15 Feb 2016

Abstract excerpt

Non-segmented, (-)RNA viruses cause serious human diseases. Human metapneumovirus (HMPV), an emerging pathogen of this order of viruses (Mononegavirales) is one of the main causes of respiratory tract illness in children. To help elucidate the assembly mechanism of the nucleocapsid (the viral RNA genome packaged by the nucleoprotein N) we present crystallographic structures of HMPV N in its assembled RNA-bound...

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PMID: 26880565
DOI: 10.7554/elife.12627

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