Article
Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2010
Chen Mark M, Bartlett Alice I, Nerenberg Paul S, Friel Claire T, Hackenberger Christian P R, Stultz Collin M, Radford Sheena E, Imperiali Barbara
Abstract excerpt
N-linked glycosylation modulates protein folding and stability through a variety of mechanisms. As such there is considerable interest in the development of general rules to predict the structural consequences of site-specific glycosylation and to understand how these effects can be exploited in the design and development of modified proteins with advantageous properties. In this study, expressed protein ligation...
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