Article
NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2011
Kumar Himanshu, Pandey Surya, Zou Jian, Kumagai Yutaro, Takahashi Ken, Akira Shizuo, Kawai Taro
Abstract excerpt
Nucleotide-binding domain and leucine rich repeat containing gene family receptors (NLRs) are cytosolic proteins that respond to a variety of pathogen and host components to induce inflammatory cytokines. NLRC5 is a recently identified member of the NLR family that has been implicated in positive and negative regulation of antiviral innate immune responses. To clarify whether NLRC5 controls antiviral innate...
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