Article
A mutation in the NLRC5 promoter limits NF-κB signaling after Salmonella Enteritidis infection in the spleen of young chickens.
Gene - 1 Sept 2015
Chang Guobin, Liu Xiangping, Ma Teng, Xu Lu, Wang Hongzhi, Li Zhiteng, Guo Xiaomin, Xu Qi, Chen Guohong
Abstract excerpt
To date, the functions of the NLRC5 in chickens remain undefined. In the current study, chicken NLRC5 was cloned and an A1017G mutation was detected in its promoter region. The relative expression levels of the NLRC5 and key NF-κB pathway genes, IKKα, IKKβ, NF-κB, IL-6, IL-1β and IFN-γ, in the sp...
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