Article
Identification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts.
Genome research - 1 Jan 2011
Borel Christelle, Deutsch Samuel, Letourneau Audrey, Migliavacca Eugenia, Montgomery Stephen B, Dimas Antigone S, Vejnar Charles E, Attar Homa, Gagnebin Maryline, Gehrig Corinne, Falconnet Emilie, Dupré Yann, Dermitzakis Emmanouil T, Antonarakis Stylianos E
Abstract excerpt
MicroRNAs (miRNAs) are regulatory noncoding RNAs that affect the production of a significant fraction of human mRNAs via post-transcriptional regulation. Interindividual variation of the miRNA expression levels is likely to influence the expression of miRNA target genes and may therefore contribute to phenotypic differences in humans, including susceptibility to common disorders. The extent to which miRNA levels...
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