Article
Copy number variations burden on miRNA genes reveals layers of complexities involved in the regulation of pathways and phenotypic expression.
PloS one - 1 Jan 2014
Veerappa Avinash M, Murthy Megha N, Vishweswaraiah Sangeetha, Lingaiah Kusuma, Suresh Raviraj V, Nachappa Somanna Ajjamada, Prashali Nelchi, Yadav Sangeetha Nuggehalli, Srikanta Manjula Arsikere, Manjegowda Dinesh S, Seshachalam Keshava B, Ramachandra Nallur B
Abstract excerpt
MicroRNAs are involved in post-transcriptional down-regulation of gene expression. Variations in miRNA genes can severely affect downstream-regulated genes and their pathways. However, population-specific burden of CNVs on miRNA genes and the complexities created towards the phenotype is not known. From a total of 44109 CNVs investigated from 1715 individuals across 12 populations using high-throughput arrays,...
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