Article
Genetic control of primary microRNA insight into cis- and trans-regulatory variations by RNA-seq.
Gene - 1 Apr 2013
Zhang Shaojun, Xu Liangde, Wang Fang, Wang Hongzhi, Gong Binsheng, Zhang Fan, Li Xia, Wang Yadong
Abstract excerpt
To search for genetic regulators influencing miRNA transcript abundance, we performed a genome-wide association study (GWAS) to identify quantitative trait loci associated with primary miRNA transcript abundance (pri-miQTL) using genotype data from HapMap CEU phased data. We detected robust expression for 150 pri-miRNAs out of 1523 interrogated using RNA-seq. We have identified some pri-miRNAs that showed...
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