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Article

P-selectin glycoprotein ligand-1 VNTR polymorphisms and risk of thrombosis in the antiphospholipid syndrome.

Annals of the rheumatic diseases - 1 Oct 2007

Diz-Kucukkaya Reyhan, Inanc Murat, Afshar-Kharghan Vahid, Zhang Q Ed, López José A, Pekcelen Yuksel

Abstract excerpt

OBJECTIVES: Antiphospholipid antibodies (aPLA) have been shown to enhance thrombus formation by increasing the expression of adhesive receptors such as P-selectin on endothelial cells. The P-selectin counter-receptor on leucocytes is P-selectin glycoprotein ligand-1 (PSGL-1). We have previously described a variable number of tandem repeats (VNTR) polymorphism in the mucin-like region of PSGL-1, with three...

Topics

Adolescent
Adult
Antiphospholipid Syndrome
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Membrane Glycoproteins
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Minisatellite Repeats

Polymorphism, Genetic

Risk Factors

Thrombosis

Source

Open in PubMed Open full text

Identifiers

PMID: 17545190
DOI: 10.1136/ard.2007.075945
PMCID: PMC1994305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17545190-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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