Article
The interplay between evolution, regulation and tissue specificity in the Human Hereditary Diseasome.
BMC genomics - 2 Dec 2010
Nagaraj Shivashankar H, Ingham Aaron, Reverter Antonio
Abstract excerpt
BACKGROUND: Human disease genes can be distinguished from essential (embryonically lethal) and non-disease genes using gene attributes. Such attributes include gene age, tissue specificity of expression, regulatory capacity, sequence length, rate of sequence variation and capacity for interaction. The resulting information has been used to inform data mining approaches seeking to identify novel disease genes....
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