Article
A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk.
Breast cancer research and treatment - 1 Jun 2011
Wang Furu, Hu Zhibin, Yang Rongxi, Tang Jinhai, Liu Yao, Hemminki Kari, Sutter Christian, Wappenschmidt Barbara, Niederacher Dieter, Arnold Norbert, Meindl Alfons, Bartram Claus R, Schmutzler Rita K, Burwinkel Barbara, Shen Hongbing
Abstract excerpt
Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the...
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