Article
Shift work, circadian gene variants and risk of breast cancer.
Cancer epidemiology - 1 Oct 2013
Grundy Anne, Schuetz Johanna M, Lai Agnes S, Janoo-Gilani Rozmin, Leach Stephen, Burstyn Igor, Richardson Harriet, Brooks-Wilson Angela, Spinelli John J, Aronson Kristan J
Abstract excerpt
Circadian (clock) genes have been linked with several functions relevant to cancer, and epidemiologic research has suggested relationships with breast cancer risk for variants in NPAS2, CLOCK, CRY2 and TIMELESS. Increased breast cancer risk has also been observed among shift workers, suggesting p...
Topics
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
- British Columbia
- Carcinoma in Situ
- Case-Control Studies
- Circadian Clocks
- Female
- Gene-Environment Interaction
- Humans
- Middle Aged
- Occupational Diseases
- Ontario
- Polymorphism, Single Nucleotide
- Work Schedule Tolerance
- Young Adult