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Article

The C-terminal region of the exosome-associated protein Rrp47 is specifically required for box C/D small nucleolar RNA 3'-maturation.

The Journal of biological chemistry - 11 Feb 2011

Costello Joe L, Stead Jonathan A, Feigenbutz Monika, Jones Rebecca M, Mitchell Phil

Abstract excerpt

Cells lacking the exosome-associated protein Rrp47 show similar defects in stable RNA processing to those observed in the absence of the catalytic subunit Rrp6, but the precise mechanism(s) by which Rrp47 functions together with Rrp6 remains unclear. Deletion complementation analyses defined an N-terminal region of Rrp47, largely coincident with the bioinformatically defined Sas10/C1D domain, which was sufficient...

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Share to Exoribonucleases
Share to Exosome Multienzyme Ribonuclease Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Ribonucleoproteins, Small Nucleolar

Share to RNA-Binding Proteins

Share to RNA Processing, Post-Transcriptional

Share to RNA, Small Nucleolar

Share to Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 21135092
DOI: 10.1074/jbc.M110.162826
PMCID: PMC3039359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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