Article
Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits.
RNA (New York, N.Y.) - 1 Feb 2002
Adams Cynthia C, Jakovljevic Jelena, Roman Judibelle, Harnpicharnchai Piyanun, Woolford John L
Abstract excerpt
To identify new gene products that participate in ribosome biogenesis, we carried out a screen for mutations that result in lethality in combination with mutations in DRS1, a Saccharomyces cerevisiae nucleolar DEAD-box protein required for synthesis of 60S ribosomal subunits. We identified the gene NOP7that encodes an essential protein. The temperature-sensitive nop7-1 mutation or metabolic depletion of Nop7p...
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