Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors.

International journal of oncology - 1 Feb 2011

Koelz Marita, Lense Josefine, Wrba Fritz, Scheffler Melanie, Dienes Hans Peter, Odenthal Margarete

Abstract excerpt

Gastrointestinal stromal tumors (GISTs), are characterized by mutations of the KIT or platelet-derived growth factor receptor-α gene and the constitutive expression of Kit, which is currently being studied as a potential therapeutic target. In this study, we addressed the question of whether the microRNA (miRNA) 221/222 cluster (miR-221/222), which has been shown to be dysregulated in many malignancies, is linked...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to MicroRNAs

Share to Paraffin Embedding

Share to Prognosis

Share to Proto-Oncogene Proteins c-kit

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 21132270
DOI: 10.3892/ijo.2010.857

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors.PMID 21132270Read ↗

miRNA‐221 and miRNA‐222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumoursSemantic proximity Read ↗

MicroRNA expression signature in gastrointestinal stromal tumour & their molecular & histological featuresSemantic proximity Read ↗

MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumoursSemantic proximity Read ↗

miRNA profiling in gastrointestinal stromal tumors: implication as diagnostic and prognostic markers.Semantic proximity Read ↗

Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31.Semantic proximity Read ↗

miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KITSemantic proximity Read ↗

Multiple sporadic gastrointestinal stromal tumors concomitant with ampullary adenocarcinoma: a case report with KIT and PDGFRA mutational analysis and miR-221/222 expression profile.Semantic proximity Read ↗

Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastomaSemantic proximity Read ↗

Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunits.Semantic proximity Read ↗

Silencing microRNA‐221/222 cluster suppresses glioblastoma angiogenesis by suppressor of cytokine signaling‐3‐dependent JAK/STAT pathwaySemantic proximity Read ↗

MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK.Semantic proximity Read ↗

MicroRNA-221 mediates the effects of PDGF-BB on migration, proliferation, and the epithelial-mesenchymal transition in pancreatic cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.