Article
Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunits.
Neoplasia (New York, N.Y.) - 1 Nov 2010
Brioschi Matteo, Fischer John, Cairoli Roberto, Rossetti Stefano, Pezzetti Laura, Nichelatti Michele, Turrini Mauro, Corlazzoli Francesca, Scarpati Barbara, Morra Enrica, Sacchi Nicoletta, Beghini Alessandro
Abstract excerpt
Core-binding factor leukemia (CBFL) is a subgroup of acute myeloid leukemia (AML) characterized by genetic mutations involving the subunits of the core-binding factor (CBF). The leukemogenesis model for CBFL posits that one, or more, gene mutations inducing increased cell proliferation and/or inhibition of apoptosis cooperate with CBF mutations for leukemia development. One of the most common mutations associated...
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