Article
Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 2010
Brodland G Wayne, Conte Vito, Cranston P Graham, Veldhuis Jim, Narasimhan Sriram, Hutson M Shane, Jacinto Antonio, Ulrich Florian, Baum Buzz, Miodownik Mark
Abstract excerpt
The absence of tools for mapping the forces that drive morphogenetic movements in embryos has impeded our understanding of animal development. Here we describe a unique approach, video force microscopy (VFM), that allows detailed, dynamic force maps to be produced from time-lapse images. The forces at work in an embryo are considered to be decomposed into active and passive elements, where active forces originate...
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