Article
Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers.
Archives of general psychiatry - 1 Jan 2009
Ernst Carl, Deleva Vesselina, Deng Xiaoming, Sequeira Adolfo, Pomarenski Amanda, Klempan Tim, Ernst Neil, Quirion Remi, Gratton Alain, Szyf Moshe, Turecki Gustavo
Abstract excerpt
CONTEXT: Although most of the effort to understand the neurobiology of depressive states and suicide has focused on neuronal processes, recent studies suggest that astroglial dysfunction may play an important role. A truncated variant of the tropomyosin-related kinase B (TrkB.T1) is expressed in...
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