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Article

Exploring the link between germline and somatic genetic alterations in breast carcinogenesis.

PloS one - 22 Nov 2010

Bonifaci Núria, Górski Bohdan, Masojć Bartlomiej, Wokołorczyk Dominika, Jakubowska Anna, Dębniak Tadeusz, Berenguer Antoni, Serra Musach Jordi, Brunet Joan, Dopazo Joaquín, Narod Steven A, Lubiński Jan, Lázaro Conxi, Cybulski Cezary, Pujana Miguel Angel

Abstract excerpt

Recent genome-wide association studies (GWASs) have identified candidate genes contributing to cancer risk through low-penetrance mutations. Many of these genes were unexpected and, intriguingly, included well-known players in carcinogenesis at the somatic level. To assess the hypothesis of a germline-somatic link in carcinogenesis, we evaluated the distribution of somatic gene labels within the ordered results...

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Source

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Identifiers

PMID: 21124932
DOI: 10.1371/journal.pone.0014078
PMCID: PMC2989917

Genes

CDKL2
DYRK2
EPHA3
EPHA7
EPHB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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