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Article

Association of Germline Variation in Driver Genes with Breast Cancer Risk in Chilean Population.

International journal of molecular sciences - 8 Nov 2023

Morales-Pison Sebastián, Tapia Julio C, Morales-González Sarai, Maldonado Edio, Acuña Mónica, Calaf Gloria M, Jara Lilian

Abstract excerpt

Cancer is a genomic disease, with driver mutations contributing to tumorigenesis. These potentially heritable variants influence risk and underlie familial breast cancer (BC). This study evaluated associations between BC risk and 13 SNPs in driver genes MAP3K1, SF3B1, SMAD4, ARID2, ATR, KMT2C, MAP3K13, NCOR1, and TBX3, in BRCA1/2-negative Chilean families. SNPs were genotyped using TaqMan Assay in 492 cases and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38003265
DOI: 10.3390/ijms242216076
PMCID: PMC10671568

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