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Article

Apolipoprotein E ε4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis.

Dementia and geriatric cognitive disorders - 1 Jan 2011

Crean Sheila, Ward Alex, Mercaldi Catherine J, Collins Jenna M, Cook Michael N, Baker Nicole L, Arrighi H Michael

Abstract excerpt

BACKGROUND: The ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. METHODS: A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. RESULTS: Although estimates varied significantly by study design and case definition, AD patients...

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Source

Identifiers

PMID: 21124030
DOI: 10.1159/000321984

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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