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Human IgG Subclasses:In VitroNeutralization of andIn VivoProtection against West Nile Virus

2 Dec 2010

Abstract excerpt

West Nile virus (WNV)-neutralizing intravenous immune globulins (IVIG) were fractionated into IgG subclasses, and the contribution of each subclass to in vitro neutralization of and in vivo protection against WNV was evaluated. The results indicate that IgG1 (i) is the main subclass induced following WNV infection of humans, (ii) contained nearly all the in vitro WNV neutralization capacity, and (iii) mediates...

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PMID: 21123389
DOI: 10.1128/jvi.02155-10

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