IgG subtype is correlated with efficiency of passive protection and effector function of anti-herpes simplex virus glycoprotein D monoclonal antibodies.

doi:10.1093/infdis/172.4.1108

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Article

IgG subtype is correlated with efficiency of passive protection and effector function of anti-herpes simplex virus glycoprotein D monoclonal antibodies.

The Journal of infectious diseases - 1 Oct 1995

Ishizaka S T, Piacente P, Silva J, Mishkin E M

Abstract excerpt

IgG subclasses differ in their effector functions in a variety of in vitro assays. To assess the effect of antibody subclass differences on in vivo protective efficacy against herpes simplex virus (HSV), a series of subclass switch mutants was made from an anti-HSV glycoprotein D monoclonal antib...

Topics

Animals
Antibodies, Monoclonal
Antibodies, Viral
Female
Herpes Simplex
Herpesvirus 2, Human
Immunization, Passive
Immunoglobulin Class Switching
Immunoglobulin G
Mice
Mice, Inbred BALB C
Mutation
Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 7561190
DOI: 10.1093/infdis/172.4.1108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7561190-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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