T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): oligoclonality of PBC-derived T cell clones.

doi:10.1002/eji.1830200426

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Article

T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): oligoclonality of PBC-derived T cell clones.

European journal of immunology - 1 Apr 1990

Moebius U, Manns M, Hess G, Kober G, Meyer zum Büschenfelde K H, Meuer S C

Abstract excerpt

Immunological events are involved in the pathophysiology of chronic active hepatitis as indicated from the accumulation of T lymphocytes at the site of tissue damage. We generated T cell clones from liver biopsies of 3 patients with chronic active hepatitis B and 2 patients with primary biliary cirrhosis. These T cell clones (n = 84) were analyzed by means of T cell receptor (TcR) beta gene rearrangements to...

Topics

Adult
Aged
Antigens, Differentiation, T-Lymphocyte
Autoimmune Diseases
CD4 Antigens
CD8 Antigens
Clone Cells
Female
Gene Rearrangement, T-Lymphocyte
Hepatitis, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Liver

Liver Cirrhosis, Biliary

Middle Aged

Phenotype

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 2112095
DOI: 10.1002/eji.1830200426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2112095-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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