Article
Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia.
Gastroenterology - 1 Jul 2007
Mack Cara L, Falta Michael T, Sullivan Andrew K, Karrer Frederick, Sokol Ronald J, Freed Brian M, Fontenot Andrew P
Abstract excerpt
BACKGROUND & AIMS: Biliary atresia is an inflammatory, fibrosclerosing neonatal cholangiopathy, characterized by a periductal infiltrate composed of CD4(+) and CD8(+) T cells. The pathogenesis of this disease has been proposed to involve a virus-induced, subsequent autoreactive T cell-mediated bile duct injury. Antigen-specific T-cell immunity involves clonal expansion of T cells expressing similar T-cell...
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