Article
T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis.
The Journal of clinical investigation - 1 Jun 1996
Duncan S R, Valentine V, Roglic M, Elias D J, Pekny K W, Theodore J, Kono D H, Theofilopoulos A N
Abstract excerpt
Obliterative bronchiolitis (OB) is the most serious late complication of lung transplantation, but the pathogenesis of this disorder has not been elucidated. We sought evidence that OB is mediated by a cellular immunologic response by characterizing T cell antigen receptor beta-chain variable gen...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Bronchiolitis Obliterans
- Clonal Anergy
- Cloning, Molecular
- DNA Primers
- Gene Expression
- Genetic Variation
- Humans
- Lung Transplantation
- Molecular Sequence Data
- Polymerase Chain Reaction
- Postoperative Complications