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Article

Association of clonally expanded T cells with the syndrome of primary biliary cirrhosis and limited scleroderma.

Hepatology (Baltimore, Md.) - 1 Jun 1999

Mayo M J, Jenkins R N, Combes B, Lipsky P E

Abstract excerpt

Clinical features of the CREST (calcinosis cutis, Raynaud's syndrome, esophageal dysmotility, sclerodactyly, and telangiectasias) syndrome are sometimes exhibited in patients with primary biliary cirrhosis (PBC), but the postulated autoimmune mechanisms behind these conditions are poorly understood. Clonally expanded T cells may play an important role in disease pathogenesis. In this study, overrepresentation of...

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Source

Identifiers

PMID: 10347101
DOI: 10.1002/hep.510290637

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