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Article

Intrahepatic B cell clonal expansions and extrahepatic manifestations of chronic HCV infection

19 Dec 2003

Abstract excerpt

B cell repertoire in three biological compartments (liver, bone marrow and peripheral blood) of 30 unselected patients chronically infected with HCV has been characterized. Restriction of humoral immune response defined by enrichment of B cell clonal expansions occurred in the liver of 15 patients (50%), in the bone marrow and peripheral blood of 2 (6.7%) and 8 (26.7%) patients, respectively. An in situ...

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PMID: 14971038
DOI: 10.1002/eji.200324328

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