Germline stem cell maintenance as a proximate mechanism of life-history trade-offs? Drosophila selected for prolonged fecundity have a slower rate of germline stem cell loss.

Abstract excerpt

We suggest that the commonly observed trade-offs between early- and late-life reproduction may be mediated by genetic variation in germline stem cell maintenance. Stem cell biology provides a natural framework and experimental methods for understanding the mechanistic basis of life-history evolution. At the same time, natural variation in life-history strategies can serve as a powerful tool for identifying the...

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