Article
TGF-α gene variations and increased susceptibility of gastric cancer in an Eastern Chinese Han population.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Feb 2014
Wu Juan, Tong Shujuan, Zhan Zhen, Zhang Junfeng, Chen Che, Hu Shouyou, Wang Ruiping
Abstract excerpt
Transforming growth factor-alpha (TGF-α) correlates with deep invasion, advanced stage and poor prognosis in gastric cancer. Genetic variants in the 3' untranslated region (UTR) of TGF-α gene may influence the stability and post-transcriptional regulation of mRNA and contribute to gastric cancer predisposition. To test this hypothesis, we genotyped five polymorphisms in 3'UTR (rs3771527, rs503314, rs473698,...
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