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Article

Genetic polymorphisms of transforming growth factor beta-1 promoter and primary biliary cirrhosis in Japanese patients.

Annals of the New York Academy of Sciences - 1 Sept 2007

Kikuchi Kentaro, Tanaka Atsushi, Matsushita Masanao, Kitazawa Eriko, Hosoya Naomi, Kawashima Yumi, Selmi Carlo, Gershwin M Eric, Miyakawa Hiroshi

Abstract excerpt

As suggested by concordance rates in twins, genetic factors are critical to the susceptibility and progression of primary biliary cirrhosis (PBC). Among cytokines, transforming growth factor beta-1 (TGF-beta1) plays an important role in autoimmunity and liver fibrosis and a TGF-beta1 receptor knockout mouse has been recently proposed as a model for PBC. The promoter region of the TGF-beta1 gene has two single...

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PMID: 17911416
DOI: 10.1196/annals.1423.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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