Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk.

doi:10.1007/s10549-009-0347-8

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Article

Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk.

Breast cancer research and treatment - 1 Dec 2009

Campa Daniele, McKay James, Sinilnikova Olga, Hüsing Anika, Vogel Ulla, Hansen Rikke Dalgaard, Overvad Kim, Witt Petra Mariann, Clavel-Chapelon Françoise, Boutron-Ruault Marie-Christine, Chajes Veronique, Rohrmann Sabine, Chang-Claude Jenny, Boeing Heiner, Fisher Eva, Trichopoulou Antonia, Trichopoulos Dimitrios, Palli Domenico, Villarini Anna, Sacerdote Carlotta, Mattiello Amalia, Tumino Rosario, Peeters Petra H M, van Gils Carla H, Bas Bueno-de-Mesquita H, Lund Eiliv, Chirlaque María Dolores, Sala Núria, Suarez Laudina Rodriguez, Barricarte Aurelio, Dorronsoro Miren, Sánchez Maria-José, Lenner Per, Hallmans Göran, Tsilidis Kostas, Bingham Sheila, Khaw Kay-Tee, Gallo Valentina, Norat Teresa, Riboli Elio, Rinaldi Sabina, Lenoir Gilbert, Tavtigian Sean V, Canzian Federico, Kaaks Rudolf

Abstract excerpt

Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-bindin...

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Identifiers

PMID: 19252981
DOI: 10.1007/s10549-009-0347-8

Genes

FAS
FASN
MLXIPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19252981-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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