Article
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.
Pharmacogenetics - 1 Jan 1995
Fernandez-Salguero P, Gonzalez F J
Abstract excerpt
The CYP2A subfamily has been characterized in several mammalian species including mouse, rat, rabbit, hamster, cattle and human. Marked species differences have been demonstrated in the catalytic activities and regulation of this subfamily. In humans, the CYP2A genes are found as a cluster on the...
Topics
- Animals
- Carcinogens
- Cattle
- Chromosome Mapping
- Chromosomes, Human, Pair 19
- Coumarins
- Cricetinae
- Cytochrome P-450 Enzyme System
- Gene Expression Regulation, Enzymologic
- Humans
- Liver
- Mice
- Multigene Family
- Neoplasms
- Phenotype
- Rabbits
- Rats
- Species Specificity