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Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium

1 Mar 2000

Abstract excerpt

OBJECTIVE: In order to study the role of the p53 tumour suppressor gene in the proliferation of rheumatoid arthritis (RA) synovium, we analysed the mutation of p53 in the synovial fibroblast-like type B synoviocyte from RA patients. METHODS: Synovial fibroblast-like type B synoviocytes were prepared from the synovial tissues from nine Japanese patients with RA. The p53 cDNA region from exons 4-11 was screened for...

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PMID: 10788533
DOI: 10.1093/rheumatology/39.3.262

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