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Article

PML mediates IFN-α–induced apoptosis in myeloma by regulating TRAIL induction

19 Jan 2005

Abstract excerpt

Interferon (IFN) induces expression of proapoptotic genes and has been used in the clinical treatment of multiple myeloma. The promyelocytic leukemia (PML) gene is an IFN-induced target that encodes a tumor suppressor protein. PML protein is typically localized within discrete speckled nuclear structures termed PML nuclear bodies (NBs). Multiple myeloma cells demonstrate differential responses to IFN treatment,...

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PMID: 15459016
DOI: 10.1182/blood-2004-04-1614

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