Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FoxP3, GATA‐3 and T‐bet expression in elderly asthma

28 Nov 2010

Abstract excerpt

BACKGROUND: Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation while T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Dermatology and Skin Diseases
Share to IL-33, ST2, and ILC Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21114556
DOI: 10.1111/j.1365-2222.2010.03640.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FoxP3, GATA‐3 and T‐bet expression in elderly asthmaPMID 21114556Read ↗

Shorter telomeres in children with severe asthma, an indicative of accelerated agingSemantic proximity Read ↗

Aging and human CD4(+) regulatory T cells.Semantic proximity Read ↗

The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic PatientsSemantic proximity Read ↗

Human T regulatory cells: on the way to cognition.Semantic proximity Read ↗

Low expression and hypermethylation of FOXP3 in regulatory T cells are associated with asthma in childrenSemantic proximity Read ↗

Age-Related Clinical Characteristics, Inflammatory Features, Phenotypes, and Treatment Response in Asthma.Semantic proximity Read ↗

Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.Semantic proximity Read ↗

Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma.Semantic proximity Read ↗

Transcriptional characteristics of CD4+ T cells in young asthmatic children: RORC and FOXP3 axisSemantic proximity Read ↗

Role of Regulatory T cells in Airway Inflammation in Asthma.Semantic proximity Read ↗

The Th17/Treg balance is disturbed during aging.Semantic proximity Read ↗

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.