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Article

Transcriptional characteristics of CD4+ T cells in young asthmatic children: RORC and FOXP3 axis

1 Nov 2011

Abstract excerpt

BACKGROUND: Asthma is a chronic inflammatory disorder, hypothetically caused by autoreactive Th2 cells, whereas Th1 and regulatory T cells may confer protection. The development of Th subpopulations is dependent on the expression of lineage-specific transcription factors. PURPOSE: This study aimed to assess the balance of CD4(+) T cell populations in asthmatic children. METHODS: Peripheral blood mononuclear cells...

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PMID: 22259252
DOI: 10.2147/jir.s25314

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